Chapter 6. Cerebral Blood Flow and Metabolism

  1. Ruth Porter and
  2. David W. Fitzsimons
  1. M. E. Raichle

Published Online: 30 MAY 2008

DOI: 10.1002/9780470720165.ch6

Ciba Foundation Symposium 34 - Outcome of Severe Damage to the Central Nervous System

Ciba Foundation Symposium 34 - Outcome of Severe Damage to the Central Nervous System

How to Cite

Raichle, M. E. (1975) Cerebral Blood Flow and Metabolism, in Ciba Foundation Symposium 34 - Outcome of Severe Damage to the Central Nervous System (eds R. Porter and D. W. Fitzsimons), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470720165.ch6

Author Information

  1. Division of Radiation Sciences, The Edward Mallinckrodt Institute of Radiology and the Department of Neurology and Neurosurgery (Neurology), Washington University School of Medicine, St. Louis, Missouri

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1975

ISBN Information

Print ISBN: 9789021940380

Online ISBN: 9780470720165

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Keywords:

  • metabolism;
  • pharmaceuticals;
  • pathophysiology;
  • cerebral blood flow;
  • human brain

Summary

To date, regional measurements of cerebral blood flow in humans have not been especially helpful in predicting the outcome of acute brain injury. The recent appearance within the medical environment of biologically significdnt pharmaceuticals labelled with the positron-emitting isotopes 15O, 13N and 11C has made possible the quantitative regional measurement of cerebral metabolism in humans. This advance, coupled with the development of radically new detection systems, will allow the safe measurement of truly regional blood flow and metabolism in humans in the near future. Such information is basic to an understanding of the pathophysiology of acute injury to the brain and the rational prediction of outcome in the individual case.