Chapter 12. Toxicological Implications of Polymorphic Drug Metabolism

  1. David Evered and
  2. Geralyn Lawrenson
  1. J.C. Ritchie,
  2. T.P. Sloan,
  3. J.R. Idle and
  4. R.L. Smith

Published Online: 30 MAY 2008

DOI: 10.1002/9780470720592.ch12

Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

How to Cite

Ritchie, J.C., Sloan, T.P., Idle, J.R. and Smith, R.L. (1980) Toxicological Implications of Polymorphic Drug Metabolism, in Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease (eds D. Evered and G. Lawrenson), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470720592.ch12

Author Information

  1. Department of Biochemical and Experimental Pharmacology, St Mary's Hospital Medical, School, Norfolk Place, London W2, UK

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1980

ISBN Information

Print ISBN: 9780444901576

Online ISBN: 9780470720592

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Keywords:

  • polymorphic drug metabolism;
  • toxic substances;
  • phenotype;
  • metabolic reactions;
  • genetic polymorphinsms

Summary

This chapter contains section titled:

  • Genetic Polymorphisms of Drug Metabolism

  • Toxicological Implications of Polymorphic Drug Metabolism

  • Genetic Polymorphism of Metabolic Oxidation

  • Presystemic Metabolism of Drugs and Genetic Polymorphism of Oxidation

  • Oxidation Phenotype and Alternative (Toxic) Pathway Metabolism

  • Oxidation Phenotype and Metiamide-Induced Agranulocytosis

  • References

  • Discussion