Chapter 4. Effects of Inducers and Inhibitors on Drug-Metabolizing Enzymes and on Drug Toxicity in Extrahepatic Tissues

  1. David Evered and
  2. Geralyn Lawrenson
  1. Michael R. Boyd

Published Online: 30 MAY 2008

DOI: 10.1002/9780470720592.ch4

Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

How to Cite

Boyd, M. R. (1980) Effects of Inducers and Inhibitors on Drug-Metabolizing Enzymes and on Drug Toxicity in Extrahepatic Tissues, in Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease (eds D. Evered and G. Lawrenson), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470720592.ch4

Author Information

  1. Molecular Toxicology Section, Clinical Pharmacology Branch, Division of Cancer Treatment, National Cancer Institute, Bethesda, Maryland 20205, USA

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1980

ISBN Information

Print ISBN: 9780444901576

Online ISBN: 9780470720592

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Keywords:

  • inducers;
  • drug-metabolising enzymes;
  • extrahepatic distribution;
  • detoxification;
  • bromobenezene

Summary

This chapter contains section titled:

  • Extrahepatic Drug-Metabolism: General Considerations

  • Roles of Drug-Metabolizing Enzymes in Extrahepatlc Toxlcity Parent Compound Versus Active Metabolites

  • Predictions of Effects of Inhibitors And Inducers of and Toxicity Drug-Metabolizing Enzymes On Extrahepatic Drug Metabolism

  • Effects of Inducers and Inhibitors on Toxicity Of Active Metabolites

  • Effects of Inducers and Inhibitors on Toxicity of Active Metabolites (Mechanisms B) in the Lung

  • References

  • Discussion