Chapter 8. Substrate-Dependent Irreversible Inactivation of Cytochrome P-450: Conversion of Its Haem Moiety into Modified Porphyrins

  1. David Evered and
  2. Geralyn Lawrenson
  1. Francesco De Matteis,
  2. Anthony H. Gibbs,
  3. Lavinia Cantoni and
  4. Jean Francis

Published Online: 30 MAY 2008

DOI: 10.1002/9780470720592.ch8

Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease

How to Cite

De Matteis, F., Gibbs, A. H., Cantoni, L. and Francis, J. (1980) Substrate-Dependent Irreversible Inactivation of Cytochrome P-450: Conversion of Its Haem Moiety into Modified Porphyrins, in Ciba Foundation Symposium 76 - Environmental Chemicals, Enzyme Function and Human Disease (eds D. Evered and G. Lawrenson), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470720592.ch8

Author Information

  1. Biochemical Pharmacology Section, Toxicology Unit, Medical Research Council Laboratories, Woodmansterne Road, Carshalton, Surrey SM5 4EF, UK

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1980

ISBN Information

Print ISBN: 9780444901576

Online ISBN: 9780470720592

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Keywords:

  • haem moitey;
  • porphyrins;
  • inactivation;
  • protoporphyrin;
  • bathochromic shifts

Summary

This chapter contains section titled:

  • Alterations of the Porphyrin Nucleus of Cytochrome P-450 in the Liver Caused by Treatment with Drugs Containing Unsaturated Substituents

  • Spectral Studies of the Green Pigments

  • Acknowledgements

  • References

  • Discussion

  • General discussion I