Chapter 4. The Genetic Basis of Autoimmune Disease

  1. David Evered,
  2. Julie Whelan
  1. J. G. Knight,
  2. D. D. Adams

Published Online: 30 MAY 2008

DOI: 10.1002/9780470720721.ch4

Book Title

Ciba Foundation Symposium 90 - Receptors, Antibodies and Disease

Ciba Foundation Symposium 90 - Receptors, Antibodies and Disease

Additional Information

How to Cite

Knight, J. G. and Adams, D. D. (2008) The Genetic Basis of Autoimmune Disease, in Ciba Foundation Symposium 90 - Receptors, Antibodies and Disease (eds D. Evered and J. Whelan), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470720721.ch4

Author Information

  1. MRC Autoimmunity Research Unit, Medical Research Council of New Zealand, University of Otago Medical School, P.O. Box 913, Dunedin, New Zealand

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1982

ISBN Information

Print ISBN: 9780272796542

Online ISBN: 9780470720721

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Keywords:

  • autoimmune disease;
  • genetic predisposition;
  • major histocompatibility complex;
  • dominant genes;
  • family history

Summary

This Chapter Contains Section Title:

  • The Genetic Predisposition to Autoimmune Diseases

  • Transmission of Specificity

  • Patterns of Inheritance

  • The V gene Theory of Inherited Autoimmune Disease

  • The Genetic Basis of Autoimmunity in New Zealand Mice

  • Other Animal Models Illustrating Genetic Determination of Autoimmune Disease

  • HLA and Disease Associations

  • A New Explanation for the Effect of Histocompatibility Antigens and Sex on Predisposition to Autoimmune Disease

  • The Genetic Association Between Autoimmune Diseases in Man

  • Reference

  • Discussion

  • Reference

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