Chapter 7. Autoantibodies to Insulin Receptors in Man: Immunological Determinants and Mechanism of Action

  1. David Evered,
  2. Julie Whelan
  1. C. Ronald Kahn1,
  2. Masato Kasuga1,
  3. George L. King1,
  4. Carl Grunfeld2

Published Online: 30 MAY 2008

DOI: 10.1002/9780470720721.ch7

Book Title

Ciba Foundation Symposium 90 - Receptors, Antibodies and Disease

Ciba Foundation Symposium 90 - Receptors, Antibodies and Disease

Additional Information

How to Cite

Kahn, C. R., Kasuga, M., King, G. L. and Grunfeld, C. (2008) Autoantibodies to Insulin Receptors in Man: Immunological Determinants and Mechanism of Action, in Ciba Foundation Symposium 90 - Receptors, Antibodies and Disease (eds D. Evered and J. Whelan), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470720721.ch7

Author Information

  1. 1

    Elliott P. Joslin Research Laboratory and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02215

  2. 2

    Veterans Administration Hospital, University of California, San Francisco, California 94121, USA

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1982

ISBN Information

Print ISBN: 9780272796542

Online ISBN: 9780470720721

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Keywords:

  • autoantibodies;
  • insulin receptors;
  • immunological determinants;
  • membrane glycoprotein;
  • gamma globulins

Summary

This Chapter Contains Section Title:

  • Clinical Syndromes Associated With Antibodies to the Insulin Receptor

  • Assays of Insulin Receptors and Receptor Antibodies

  • Structure and Antigenic Determinants of the Insulin Receptor

  • Fate of Anti-Receptor Antibody Bound to Cells

  • Mechanism of Antibody Effects on Cell Function

  • Possible Aetiology of Antibodies to the Insulin Receptors

  • Reference

  • Dissussion

  • Reference

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