Chapter 4. Synthesis of Collagen: Chemical Regulation of Post-Translational Events

  1. David Evered,
  2. Julie Whelan
  1. Kari I. Kivirikko,
  2. Kari Majamaa

Published Online: 30 MAY 2008

DOI: 10.1002/9780470720950.ch4

Book Title

Ciba Foundation Symposium 114 - Fibrosis

Ciba Foundation Symposium 114 - Fibrosis

Additional Information

How to Cite

Kivirikko, K. I. and Majamaa, K. (2008) Synthesis of Collagen: Chemical Regulation of Post-Translational Events, in Ciba Foundation Symposium 114 - Fibrosis (eds D. Evered and J. Whelan), John Wiley & Sons, Ltd., Chichester, UK. doi: 10.1002/9780470720950.ch4

Author Information

  1. Collagen Research Unit, University of Oulu, Department of Medical Biochemistry, SF-90220 Oulu, Finland

Publication History

  1. Published Online: 30 MAY 2008
  2. Published Print: 1 JAN 1985

ISBN Information

Print ISBN: 9780272798140

Online ISBN: 9780470720950

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Keywords:

  • collagen biosynthesis;
  • chemical regulation;
  • cleavage of propeptides;
  • procollagen molecules;
  • prolyl 4-hydroxylase

Summary

This chapter contains section titled:

  • Inhibition of the 4-Hydroxylation of Proline Residues

  • Inhibition of Collagen Triple Helix Formation by the Administration of Proline Analogues

  • Inhibition of the Cleavage of Propeptides

  • Inhibition of Cross-Link Formation

  • Conclusions

  • References

  • Discussion

  • Prolyl and Lysyl Hydroxylases

  • N-and C-Proteinase Inhibitors

  • Targeting of Antifibrotic Agents

  • Inhibition of Cross-Linking

  • Stimulation of Collagenase Activity

  • Regulation of Early Events in Collagen Synthesis

  • Assessment of New Antifibrotic Drugs

  • References

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