Mechanisms of Mitochondrial Outer Membrane Permeabilization

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Dominic James,
  2. Philippe A. Parone,
  3. Olivier Terradillos,
  4. Safa Lucken-Ardjomande,
  5. Sylvie Montessuit and
  6. Jean-Claude Martinou

Published Online: 20 MAY 2008

DOI: 10.1002/9780470725207.ch12

Mitochondrial Biology: New Perspectives: Novartis Foundation Symposium 287

Mitochondrial Biology: New Perspectives: Novartis Foundation Symposium 287

How to Cite

James, D., Parone, P. A., Terradillos, O., Lucken-Ardjomande, S., Montessuit, S. and Martinou, J.-C. (2007) Mechanisms of Mitochondrial Outer Membrane Permeabilization, in Mitochondrial Biology: New Perspectives: Novartis Foundation Symposium 287 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470725207.ch12

Author Information

  1. Department of Cell Biology, Sciences III, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva 4, Switzerland

Publication History

  1. Published Online: 20 MAY 2008
  2. Published Print: 5 OCT 2007

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470066577

Online ISBN: 9780470725207

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Keywords:

  • mitochondria;
  • apoptosis;
  • fission;
  • cytochrome c;
  • Smac/DIABLO;
  • Bax;
  • membrane permeabilization;
  • Drp-1;
  • Bid

Summary

In response to many apoptotic stimuli, Bcl-2 family pro-apoptotic members, such as Bax and Bak, are activated. This results in their oligomerization, permeabilization of the outer mitochondrial membrane, and release of many proteins that are normally confined in the mitochondrial inter-membrane space. Among these proteins are cytochrome c, Smac/DIABLO, OMI/HtrA2, AIF and endonuclease G. Mitochondrial outer membrane permeabilization (MOMP) is also associated with fragmentation of the mitochondrial network. The mechanisms that lead to the oligomerization of proapoptotic members of the Bcl-2 family and to MOMP are still unclear and the role of mitochondrial fission in these events remains elusive.