Endoplasmic Reticulum/Mitochondria Calcium Cross-Talk

  1. Derek J. Chadwick Organizer and
  2. Jamie Goode
  1. Anna Romagnoli,
  2. Paola Aguiari,
  3. Diego De Stefani,
  4. Sara Leo,
  5. Saverio Marchi,
  6. Alessandro Rimessi,
  7. Erika Zecchini,
  8. Paolo Pinton and
  9. Rosario Rizzuto

Published Online: 20 MAY 2008

DOI: 10.1002/9780470725207.ch9

Mitochondrial Biology: New Perspectives: Novartis Foundation Symposium 287

Mitochondrial Biology: New Perspectives: Novartis Foundation Symposium 287

How to Cite

Romagnoli, A., Aguiari, P., De Stefani, D., Leo, S., Marchi, S., Rimessi, A., Zecchini, E., Pinton, P. and Rizzuto, R. (2007) Endoplasmic Reticulum/Mitochondria Calcium Cross-Talk, in Mitochondrial Biology: New Perspectives: Novartis Foundation Symposium 287 (eds D. J. Chadwick and J. Goode), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470725207.ch9

Author Information

  1. ER-GenTech and Interdisciplinary Center for the Study of Inflammation, Department of Experimental and Diagnostic Medicine, General Pathology Section, University of Ferrara, Via L. Borsari 46, 44100 Ferrara, Italy

Publication History

  1. Published Online: 20 MAY 2008
  2. Published Print: 5 OCT 2007

Book Series:

  1. Novartis Foundation Symposia

Book Series Editors:

  1. Novartis Foundation

ISBN Information

Print ISBN: 9780470066577

Online ISBN: 9780470725207



  • endoplasmic reticulum;
  • mitochondrial matrix;
  • cellular metabolic memory;
  • physiological and pathological stimuli;
  • outer mitochondrial membrane


The interaction of mitochondria with the endoplasmic reticulum (ER) Ca2+ store plays a key role in allowing these organelles to rapidly and effectively respond to cellular Ca2+ signals. In this contribution, we will briefly discuss: (i) old and new concepts of mitochondrial Ca2+ homeostasis; (ii) the relationship between mitochondrial 3D structure and Ca2+ homeostasis; (iii) the modulation by cytoplasmic signalling pathways; and (iv) new data suggesting that mitochondria and ER Ca2+ channels are assembled in a macromolecular complex in which the inositol-1,4,5-trisphosphate receptor directly stimulates the mitochondrial Ca2+ uptake machinery.