Chapter 8. Structure-Based Prediction of Enzymes and Their Active Sites

  1. Janusz M. Bujnicki2,3
  1. James W. Torrance and
  2. Janet M. Thornton

Published Online: 18 DEC 2008

DOI: 10.1002/9780470741894.ch8

Prediction of Protein Structures, Functions, and Interactions

Prediction of Protein Structures, Functions, and Interactions

How to Cite

Torrance, J. W. and Thornton, J. M. (2008) Structure-Based Prediction of Enzymes and Their Active Sites, in Prediction of Protein Structures, Functions, and Interactions (ed J. M. Bujnicki), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470741894.ch8

Editor Information

  1. 2

    Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, ul. Ks. Trojdena 4, 02-109 Warsaw, Poland

  2. 3

    Laboratory of Bioinformatics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, ul. Umultowska 89, 61-614 Poznan, Poland

Author Information

  1. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK

Publication History

  1. Published Online: 18 DEC 2008
  2. Published Print: 19 DEC 2008

ISBN Information

Print ISBN: 9780470517673

Online ISBN: 9780470741894

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Keywords:

  • structure-based function prediction;
  • enzyme function and Enzyme Commission (EC) classification;
  • enzymes and active sites - structure-based prediction;
  • template searching and predicting function;
  • distant homologues and convergent evolution cases;
  • template matching methods;
  • SURFACE patch template library and program SURFNET;
  • function prediction strategy

Summary

This chapter contains sections titled:

  • Introduction

  • Identifying Homologues Using Overall Protein Structure

  • Recognising Distant Homologues and Cases of Convergent Evolution Using Template Matching Methods

  • Other Methods for Matching Parts of Structures

  • Function Prediction without Inferring Function from Homologues

  • Meta-servers for Function Prediction

  • References