Chapter 13. Hydroxylamines and Oximes: Biological Properties and Potential uses as Therapeutic Agents

  1. Professor Zvi Rappoport2 and
  2. Joel F. Liebman3
  1. Yacov Ashani and
  2. Israel Silman

Published Online: 19 DEC 2008

DOI: 10.1002/9780470741962.ch13

The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids

The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids

How to Cite

Ashani, Y. and Silman, I. (2008) Hydroxylamines and Oximes: Biological Properties and Potential uses as Therapeutic Agents, in The Chemistry of Hydroxylamines, Oximes and Hydroxamic Acids (eds Z. Rappoport and J. F. Liebman), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470741962.ch13

Editor Information

  1. 2

    The Hebrew University, Jerusalem, Israel

  2. 3

    Department of Chemistry and Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, Maryland 21250, USA

Author Information

  1. Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel

Publication History

  1. Published Online: 19 DEC 2008
  2. Published Print: 19 DEC 2008

Book Series:

  1. PATAI'S Chemistry of Functional Groups

Book Series Editors:

  1. Professor Saul Patai and
  2. Professor Zvi Rappoport

Series Editor Information

  1. The Hebrew University, Jerusalem, Israel

ISBN Information

Print ISBN: 9780470512616

Online ISBN: 9780470741962

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Keywords:

  • hydroxylamines (HAs) – natural occurrence;
  • HAs in naturally occurring antibiotic biosynthesis;
  • HA involvement and ‘nitrate ammonification’;
  • HAs and reactive oxygen species (ROS);
  • HAs - biological and therapeutic properties;
  • diverse oximes - naturally occurring products;
  • nitrile-degrading enzymes;
  • indirubin oxime derivative - cyclin-dependent kinase (CDK) potent inhibitor;
  • mono and bis-quaternary pyridine aldoximes and therapeutic efficacy

Summary

This chapter contains sections titled:

  • Introduction

  • Hydroxylamines (HAs)

  • Oximes

  • References