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Haematology and Toxicology

Methodology

  1. Timothy C. Marrs OBE, MD, DSc, FRCP, FRCPath, FBTS, FATS1,
  2. Simon Warren DABT, DIBT, DipRCPath2

Published Online: 15 DEC 2009

DOI: 10.1002/9780470744307.gat041

General, Applied and Systems Toxicology

General, Applied and Systems Toxicology

How to Cite

Marrs, T. C. and Warren, S. 2009. Haematology and Toxicology. General, Applied and Systems Toxicology. .

Author Information

  1. 1

    Edentox Associates, Edenbridge, Kent, UK

  2. 2

    Managing Toxicologist, Exponent International Ltd, Centre for Chemical Regulation and Food Safety, UK

Publication History

  1. Published Online: 15 DEC 2009

Abstract

Haematological investigations are of importance in toxicology because toxicological effects on the blood and associated organs may occur. Further, toxicological parameters are routinely measured during regulatory toxicological studies. There are important practical considerations in obtaining blood and/or bone marrow for toxicological studies. Toxicants can cause abnormalities in toxicological tests by a variety of means. Many of the techniques used in human and veterinary medicine have not been widely applied to laboratory animal toxicology studies.

Keywords:

  • blood;
  • erythrocyte;
  • leucocyte;
  • haemoglobin;
  • methaemoglobin;
  • sampling