Published Online: 15 DEC 2009
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
General, Applied and Systems Toxicology
How to Cite
Bateman, D. N. and Marrs, T. C. 2009. Antidotal Studies. General, Applied and Systems Toxicology. .
- Published Online: 15 DEC 2009
Antidotes for poisons may act in a variety of ways and, in some cases, two (or more) antidotes using different antidotal approaches, are used together. Antidote development depends on an extensive knowledge of the action of the poison, which the antidote is expected to counteract. Poisons and their antidotes may be studied in vitro, in experimental animals or in humans. The design of experimental studies in animals and experimental and observational ones in humans presents major challenges. In the case of animal studies, the aim is to simulate realistic treatment scenarios.
- clinical trials;