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Inhalation Toxicity

Toxicity by Routes

  1. Geoff H. Pigott BSc, PhD, DipRC Path

Published Online: 15 DEC 2009

DOI: 10.1002/9780470744307.gat056

General, Applied and Systems Toxicology

General, Applied and Systems Toxicology

How to Cite

Pigott, G. H. 2009. Inhalation Toxicity. General, Applied and Systems Toxicology. .

Author Information

  1. A.H. Marks and Company Ltd, Bradford, West Yorkshire, UK

Publication History

  1. Published Online: 15 DEC 2009

Abstract

Inhalation is an important route for entry of toxicants into the body. The structure of the lung is described with emphasis on those features that influence particle penetration. Properties that provide primary defence against pollutants, especially particulates are discussed. Gases aerosols and particulates which penetrate the lung defences may induce a variety of responses, both systemic and localized in the lung. The nature and aetiology of these reactions, especially those induced by particulates, (including fibrous particles) is described. The principles for modelling these responses, both in animals and in vitro, and for estimating dosimetry are discussed, together with their limitations.

Keywords:

  • inhalation;
  • gases;
  • vapours;
  • aerosols;
  • fibres;
  • particulates;
  • deposition dosimetry