Short-term Tests for the Determination of Genotoxic and Carcinogenic Potential of Xenobiotics
Genetic Toxicology, Oncogenesis, Developmental and Reproductive Toxicology
Published Online: 15 DEC 2009
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
General, Applied and Systems Toxicology
How to Cite
Dhawan, A. 2009. Short-term Tests for the Determination of Genotoxic and Carcinogenic Potential of Xenobiotics. General, Applied and Systems Toxicology. .
- Published Online: 15 DEC 2009
The advent of industrial revolution has seen a significant increase in the number of chemicals being released into the environment and it becomes imperative to check their toxic potential. Exposure to such compounds produces chemical changes in DNA, which are generally repaired by the DNA-repair enzymes. Hence, adequate tests have to be conducted for risk assessment and hazard prediction of these chemicals. Earlier, only long-term animal bioassays, involving lifetime studies on animals, were used to classify substances as mutagens/carcinogens. These tests were cumbersome, time-consuming, resource-intensive and expensive. Therefore, rapid, sensitive and less resource intensive short-term tests were developed for testing of new chemical entities. A ‘battery’ of three to four of these short-term tests has now been proposed by a number of regulatory agencies for classification of the compounds as mutagenic or carcinogenic. Although several short-term tests are available, molecular biology and in silico methods are now being developed to predict the genotoxicity and carcinogenicity of chemicals at an early stage for interventional strategies to be implemented in time.
- short-term tests;