Published Online: 15 DEC 2009
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
General, Applied and Systems Toxicology
How to Cite
Jin, C., Werntz, C. M. and Ducatman, A. M. 2009. Occupational Toxicology. General, Applied and Systems Toxicology. .
- Published Online: 15 DEC 2009
Occupational diseases are both over- and underdiagnosed. Both problems are important, but underdiagnosis in populations dwarfs the intermittent problem of occasional overdiagnosis in individuals. A Venn-diagram approach to occupational disease includes: (i) a correct clinical diagnosis (specific ICD code or else a clear description of the clinical presentation), (ii) an understanding of the patient's exposure history (toxic exposures, including some sense of ‘dose’) and (iii) an understanding of the actual human toxicology/epidemiology of the exposure(s) in question (evidence-based exposure-outcome assessment). Incomplete understanding of the clinical presentation or failure to understand the exposure explains the large background of missed diagnoses. Fanciful attributions of exposure-outcome relationships explain intermittent overdiagnoses. Following an overview of the occupational history, and laboratory testing, this chapter surveys the literature covering a broad range of toxic exposure-outcome information.
- occupational diseases/chemically induced/classification/epidemiology;
- occupational exposure;
- occupational exposure/adverse effects;
- occupational history;
- occupational medicine;
- environmental disease;
- environmental factors;