Hormesis and Risk Assessment
Issues Relevant to Toxicology
Published Online: 15 DEC 2009
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
General, Applied and Systems Toxicology
How to Cite
Calabrese, E. J. and Ricci, P. F. 2009. Hormesis and Risk Assessment. General, Applied and Systems Toxicology. .
- Published Online: 15 DEC 2009
The hormetic dose-response model has experienced a strong resurgence of interest in toxicology, risk assessment and pharmacology. This is based on its capacity for validation, reproducibility, generalizability, and its demonstrated ability to predict low-dose responses far more accurately than threshold and linear-at-low-dose models. This paper assesses capacity of hormesis models to impact the current risk assessment process, as well as the implications for risk assessment if regulatory agencies were to accept the hormetic dose-response as the default model.
- adaptive response;
- risk assessment;