Application of Quantitative Proteomic Approaches to Toxicology
Published Online: 15 SEP 2011
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
General, Applied and Systems Toxicology
How to Cite
Prasad, T. K. and Chaerkady, R. 2011. Application of Quantitative Proteomic Approaches to Toxicology. General, Applied and Systems Toxicology. .
- Published Online: 15 SEP 2011
Epidemiological and genetic studies have significantly contributed to our understanding of hazardous effects of various environmental pollutants on biological systems at a molecular level. However, only limited reports exist those describe proteomic alterations associated with toxicity of such pollutants. Proteomic signatures can be employed as biomarkers for exposure as well as toxicity. Improved protein/peptide labeling technologies have led to the development of a variety of methodologies for quantitative proteomics that can be used to obtain differential protein profiles. This review highlights various quantitative proteomic technologies, which can be applied to unravel proteomic changes in response to toxicants.
- clinical proteomics;
- mass spectrometry;
- signaling pathways