Metabolomics in Systems Toxicology: Towards Personalized Medicine
Published Online: 15 SEP 2011
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
General, Applied and Systems Toxicology
How to Cite
Schnackenberg, L. K., Sun, J. and Beger, R. D. 2011. Metabolomics in Systems Toxicology: Towards Personalized Medicine. General, Applied and Systems Toxicology.
- Published Online: 15 SEP 2011
Metabolomics along with systems biology technologies such as transcriptomics and proteomics has the capability of providing translational diagnostic, prognostic and mechanistic biomarkers of drug-induced injury. Metabolomics has several advantages over the other omics platforms, such as ease of sample preparation, data acquisition and use of biofluids collected through minimally invasive procedures in pre-clinical and clinical studies. The role of metabolomics in systems toxicology is reviewed and examples of metabolomics in pre-clinical and clinical studies are provided. The role of metabolomics in personalized medicine is provided with special sections focusing on drug–drug and drug–nutrient interactions, metabolic fluxes and challenge tests.
- metabolic fluxes;
- personalized medicine;
- systems biology