Chapter 1. Pathophysiology of Acute Coronary Syndromes

  1. Eli V. Gelfand Director of Ambulatory Cardiology2 and
  2. Christopher P. Cannon Senior Investigator Associate Professor3,4,5
  1. Alisa B. Rosen Assistant Professor of Medicine1 and
  2. Eli V. Gelfand Director of Ambulatory Cardiology2

Published Online: 9 APR 2009

DOI: 10.1002/9780470745465.ch1

Management of Acute Coronary Syndromes

Management of Acute Coronary Syndromes

How to Cite

Rosen, A. B. and Gelfand, E. V. (2009) Pathophysiology of Acute Coronary Syndromes, in Management of Acute Coronary Syndromes (eds E. V. Gelfand and C. P. Cannon), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470745465.ch1

Editor Information

  1. 2

    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

  2. 3

    TIMI Study Group, Boston, Massachusetts, USA

  3. 4

    Brigham and Women's Hospital, Boston, Massachusetts, USA

  4. 5

    Harvard Medical School, Boston, Massachusetts, USA

Author Information

  1. 1

    Boston University School of Medicine, Section of Cardiovascular Medicine, Boston Medical Center, Boston, Massachusetts, USA

  2. 2

    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA

Publication History

  1. Published Online: 9 APR 2009
  2. Published Print: 17 APR 2009

ISBN Information

Print ISBN: 9780470725573

Online ISBN: 9780470745465

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Keywords:

  • acute coronary syndrome pathophysiology;
  • acute coronary syndromes (ACS) and rupture of atherosclerotic coronary plaque with overlying acute thrombosis;
  • atherosclerotic plaque formation;
  • plaque instability and ACS development;
  • myocardial oxygen balance and related pathophysiologic factors;
  • myocardial ischemia;
  • secondary hemostasis (coagulation cascade) with platelet-mediated primary hemostatic mechanisms;
  • dynamic obstruction with epicardial coronary vasospasm;
  • progressive mechanical obstruction - cause of ACS

Summary

This chapter contains sections titled:

  • Introduction

  • Formation of atherosclerotic plaque

  • Plaque instability and the development of ACS

  • Myocardial ischemia

  • Thrombus formation

  • Platelets

  • Secondary hemostasis

  • Dynamic obstruction

  • Progressive mechanical obstruction

  • Inflammation

  • Secondary unstable angina

  • References