1. Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis

  1. Norbert F. Voelkel3 and
  2. Sharon Rounds Chief4,5
  1. Margaret A. Schwarz Associate Professor1 and
  2. Ondine B. Cleaver Assistant Professor2

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch1

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Schwarz, M. A. and Cleaver, O. B. (2009) Development of the Pulmonary Endothelium in Development of the Pulmonary Circulation: Vasculogenesis and Angiogenesis, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch1

Editor Information

  1. 3

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 4

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 5

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA

  2. 2

    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • pulmonary endothelium and pulmonary circulation;
  • vascular cell ontogeny;
  • blood islands and hemangioblasts;
  • vasculogenesis;
  • tubulogenesis;
  • sprouting angiogenesis;
  • arterial versus venous differentiation;
  • VEGF-A and isoforms;
  • angiogenesis and vasculogenesis in developing lung;
  • endothelial-specific factors

Summary

This chapter contains sections titled:

  • Introduction

  • Ontogeny of Vascular Cells

  • Ontogeny of the Vasculature

  • Arterial Versus Venous Differentiation

  • Key Molecules in Vascular Development

  • Formation of Pulmonary Vasculature

  • Origin of the Lung

  • Stages of Lung Development

  • Origin of Lung Vasculature

  • Angiogenesis and Vasculogenesis in the Developing Lung

  • Vascular Growth Factors in Lung Morphogenesis

  • Endothelial-Specific Factors

  • Non-Endothelial-Specific Growth Factors

  • Antiangiogenic Factors

  • Conclusions and Perspectives

  • Acknowledgments

  • References