11. Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation

  1. Norbert F. Voelkel4 and
  2. Sharon Rounds Chief5,6
  1. Kurt R. Stenmark1,3,
  2. Evgenia V. Gerasimovskaya1,3,
  3. Neil Davie2 and
  4. Maria Frid1,3

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch11

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Stenmark, K. R., Gerasimovskaya, E. V., Davie, N. and Frid, M. (2009) Mesenchymal–Endothelial Interactions in the Control of Angiogenic, Inflammatory, and Fibrotic Responses in the Pulmonary Circulation, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch11

Editor Information

  1. 4

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 5

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 6

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA

  2. 2

    Pulmonary Vascular Business Unit, Pfizer, Tadworth, Surrey, UK

  3. 3

    Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratories, University of Colorado Health Sciences Center, Denver, CO, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • chronic pulmonary hypertension characterized by vascular remodeling;
  • extracellular matrix (ECM) proteins;
  • resident endothelial cells (ECs) of vasa vasorum;
  • adventitial stromal cells and inflammation and angiogenesis;
  • cytokines - monocyte chemotactic protein-1 (MCP-1);
  • transforming growth factor (TGF)-β;
  • pulmonary artery ECs (PAECs) or aortic ECs (AOECs);
  • ATP exerting proangiogenic effect on cultured VVECs;
  • endothelial–mesenchymal phenotypic switch in primary culture

Summary

This chapter contains sections titled:

  • Introduction

  • Adventitial Stromal Cells: Definitions and Roles in Inflammation and Angiogenesis

  • Conclusions and Perspectives

  • References