13. Pulmonary Endothelial Progenitor Cells

  1. Norbert F. Voelkel3 and
  2. Sharon Rounds Chief4,5
  1. Bernard Thébaud1 and
  2. Mervin C. Yoder2

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch13

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Thébaud, B. and Yoder, M. C. (2009) Pulmonary Endothelial Progenitor Cells, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch13

Editor Information

  1. 3

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 4

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 5

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Department of Pediatrics, Division of Neonatology, University of Alberta, Edmonton, AB T6G 2S2, Canada

  2. 2

    Department of Pediatrics, Division of Neonatal-Perinatal Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490



  • pulmonary endothelial progenitor cells;
  • endothelial cells (ECs) and endothelial progenitor cells (EPCs);
  • circulating endothelial progenitor cells;
  • EPCs robust proliferative potential in neoangiogenesis;
  • resident EPCs;
  • pulmonary EC developmental heterogeneity;
  • isolation of pulmonary resident microvascular EPCs;
  • BPD pathophysiology and VEGF role in lung injury and repair;
  • potential role of RMEPCs in BPD


This chapter contains sections titled:

  • Introduction

  • Circulating Endothelial Progenitor Cells

  • Resident EPCs

  • Pulmonary EC Developmental Heterogeneity

  • Comparison of Pulmonary Microvascular and Macrovascular Endothelial Proliferation

  • Isolation of Pulmonary Resident Microvascular EPCs

  • Preliminary Observations on Molecule that Regulates Pulmonary Rmepc Activity In Vitro

  • Clinical Disorders Associated with Diminished Lung Growth or Remodeling

  • Vascular EC Growth Promotes Lung Development

  • Pathophysiology of BPD and Role of VEGF in Lung Injury and Repair

  • Therapeutic Potential of Angiogenic Growth Factors in Lung Disease

  • Potential Role of Rmepcs in BPD

  • Conclusions and Perspectives

  • References