17. Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium

  1. Norbert F. Voelkel2 and
  2. Sharon Rounds Chief3,4
  1. Kenneth E. Chapman,
  2. Shampa Chatterjee and
  3. Aron B. Fisher

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch17

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Chapman, K. E., Chatterjee, S. and Fisher, A. B. (2009) Oxidant-Mediated Signaling and Injury in Pulmonary Endothelium, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch17

Editor Information

  1. 2

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 3

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 4

    Medical Center, Providence, RI 02908, USA

Author Information

  1. Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • oxidant-mediated signaling and pulmonary endothelium injury;
  • oxidant stress with O2-based radicals and reactive oxygen species (ROS);
  • oxidant–antioxidant balance;
  • NO synthase (nitric oxide synthase NOS);
  • cytochrome P450 pathway of endoplasmic reticulum;
  • superoxide dismutases (SODs);
  • SOD role in cellular defense against oxidative stress;
  • ROS as signaling molecules;
  • cellular manifestations of oxidative stress;
  • endothelial injury - hallmark of acute lung injury (ALI) pathology

Summary

This chapter contains sections titled:

  • Introduction

  • Oxidant-Antioxidant Balance

  • Physiological Role of ROS

  • Cellular Manifestations of Oxidative Stress

  • Pathophysiologic Mechanisms for Oxidative Stress

  • Pulmonary Syndromes Associated with Endothelial Oxidative Stress

  • Conclusions and Perspectives

  • References