18. Hypoxia and the Pulmonary Endothelium

  1. Norbert F. Voelkel2 and
  2. Sharon Rounds Chief3,4
  1. Matthew Jankowich1,3,4,
  2. Gaurav Choudhary1,3,4 and
  3. Sharon Rounds Chief3,4

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch18

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Jankowich, M., Choudhary, G. and Rounds, S. (2009) Hypoxia and the Pulmonary Endothelium, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch18

Editor Information

  1. 2

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 3

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 4

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Vascular Research Laboratory, Providence, RI 02908, USA

  2. 3

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 4

    Medical Center, Providence, RI 02908, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • hypoxia and pulmonary endothelium;
  • cellular responses to oxygen for normal energy metabolism;
  • bovine pulmonary artery ECs (BPAECs) and bovine aortic ECs (BAECs);
  • candidates for hypoxia sensors;
  • hypoxia sensor(s);
  • hypoxia and pulmonary vascular permeability;
  • HAPE and altered lung vascular permeability in hypoxic humans;
  • pulmonary ECs and hypoxia response and modulating lung vascular responses

Summary

This chapter contains sections titled:

  • Introduction

  • Hypoxia and Pulmonary EC Metabolism, Viability, and Proliferation

  • Hypoxia Sensor(S)

  • Hypoxia and Gene Transcription

  • Other Effects of Hypoxia on Pulmonary Endothelium

  • Intermittent Versus Sustained Hypoxia and Pulmonary Endothelial Cells

  • Hypoxia and Pulmonary Vascular Permeability

  • Effects of Hypoxia on Cultured Pulmonary EC Monolayer Permeability

  • Cell Signaling and Pulmonary Endothelial Permeability

  • Effect of Hypoxia on Vascular Permeability of Isolated Perfused Lungs

  • Effect of Hypoxia on Lung Vascular Permeability in Animals

  • Hape and Altered Lung Vascular Permeability in Hypoxic Humans

  • Conclusions and Perspectives

  • References