20. Effects of Pressure and Flow on the Pulmonary Endothelium

  1. Norbert F. Voelkel5 and
  2. Sharon Rounds Chief6,7
  1. Wolfgang M. Kuebler1,2,3,4

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch20

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Kuebler, W. M. (2009) Effects of Pressure and Flow on the Pulmonary Endothelium, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch20

Editor Information

  1. 5

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 6

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 7

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    University of Toronto, Ontario, Canada

  2. 2

    Charité - Universitätsmedizin Berlin, Berlin, Germany

  3. 3

    Lung and Circulatory Research Laboratory, Institute of Physiology, Berlin, Germany

  4. 4

    The Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto M5B 1W8, Ontario, Canada

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • pressure effects and flow on pulmonary endothelium;
  • high-altitude pulmonary edema (HAPE) or ventilator-induced lung injury (VILI);
  • mechanical forces acting on pulmonary endothelium;
  • mechanotransduction in ECs;
  • acute pressure stress on pulmonary endothelium;
  • flow effects on pulmonary endothelium;
  • mechanical injury to endothelium in lung disease;
  • VILI - iatrogenic disease constituting a challenge

Summary

This chapter contains sections titled:

  • Introduction

  • Mechanical Forces Acting on the Pulmonary Endothelium

  • Mechanotransduction in ECs

  • Effects of Acute Pressure Stress on the Pulmonary Endothelium

  • Effects of Chronic Pressure Stress on the Pulmonary Endothelium

  • Effects of Flow on the Pulmonary Endothelium

  • Mechanical Injury to the Endothelium in Lung Disease

  • Conclusions and Perspectives

  • Acknowledgments

  • References