21. Therapeutic Strategies to Limit Lung Endothelial Cell Permeability

  1. Norbert F. Voelkel4 and
  2. Sharon Rounds Chief5,6
  1. Rachel K. Wolfson1,3,
  2. Gabriel Lang2,3,
  3. Jeff Jacobson2,3 and
  4. Joe G. N. Garcia3

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch21

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Wolfson, R. K., Lang, G., Jacobson, J. and Garcia, J. G. N. (2009) Therapeutic Strategies to Limit Lung Endothelial Cell Permeability, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch21

Editor Information

  1. 4

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 5

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 6

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Section of Critical Care, Chicago, IL 60637, USA

  2. 2

    Section of Pulmonary and Critical Care Medicine, Chicago, IL 60637, USA

  3. 3

    Department of Medicine, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490



  • therapeutic strategies limiting lung endothelial cell permeability;
  • vascular endothelium - primary cellular target in physiologic derangement;
  • acute (inflammatory) lung injury (ALI);
  • intracellular signaling pathways and EC edemagenic agents;
  • receptor-mediated barrier protection - role of RAC GTPase;
  • S1P;
  • sphingolipid from sphingosine phosphorylation;
  • simvastatin-mediated thrombin inhibition;
  • oxidized phospholipids;
  • methylnaltrexone (MNTX) - peripherally restricted mu opioid receptor (mOP-R) antagonist


This chapter contains sections titled:

  • Introduction

  • Signals to the EC Cytoskeleton as Targets for Barrier Restoration

  • Receptor-Mediated Barrier Protection: Role of Rac Gtpase and Cortical Actin Remodeling

  • S1P and Closely Related Analogs

  • Simvastatin

  • ATP

  • HGF

  • APC

  • Oxidized Phospholipids

  • PGs

  • Methylnaltrexone

  • Conclusions and Perspectives

  • References