22. Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium

  1. Norbert F. Voelkel3 and
  2. Sharon Rounds Chief4,5
  1. Vladimir R. Muzykantov1,2

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch22

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Muzykantov, V. R. (2009) Targeted Delivery of Biotherapeutics to the Pulmonary Endothelium, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch22

Editor Information

  1. 3

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 4

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 5

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Department of Pharmacology and Program in Targeted Therapeutics of the Institute for Translational Medicine Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6068, USA

  2. 2

    Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104-6068, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • biotherapeutics targeted delivery to pulmonary endothelium;
  • thrombomodulin (TM) and angiotensin-converting enzyme (ACE) - drug delivery targets;
  • carriers optimizing vascular pharmacokinetics of drugs;
  • vascular immunotargeting of antioxidant and fibrinolytic enzymes;
  • antibodies directed at specific endothelial domains;
  • I-labeled anti-ICAM accumulation in lungs;
  • enzyme replacement therapies;
  • antithrombotic agents

Summary

This chapter contains sections titled:

  • Introduction - Pulmonary Endothelium: a Therapeutic Target

  • Carriers Optimizing Vascular Pharmacokinetics of Drugs

  • Vascular Targeting to the Pulmonary Endothelium: Target Definition

  • Constitutively Expressed Transmembrane Glycoproteins Enriched in the Pulmonary Endothelium: ACE and TM

  • Constitutively Expressed Cell Adhesion Molecules

  • Inducible Endothelial Cams: Selectins and VCAM-1

  • Antibodies Directed to Specific Endothelial Domains

  • Drug Targeting to the Pulmonary Endothelium: Specific Applications

  • Acknowledgments

  • References