23. Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn

  1. Norbert F. Voelkel3 and
  2. Sharon Rounds Chief4,5
  1. Yuansheng Gao1 and
  2. J. Usha Raj2

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch23

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Gao, Y. and Raj, J. U. (2009) Endothelial Regulation of the Pulmonary Circulation in the Fetus and Newborn, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch23

Editor Information

  1. 3

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 4

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 5

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Department of Physiology and Pathophysiology Peking University Health Science Center, Beijing, 100191, China

  2. 2

    Department of Pediatrics, University of Illinois at Chicago, Chicago, IL 60612, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

SEARCH

Keywords:

  • endothelial regulation of pulmonary circulation in fetus and newborn;
  • high vascular resistance and low blood flow in fetus pulmonary circulation;
  • endothelium and fetal pulmonary circulation;
  • fetal pulmonary circulation and endothelium-derived vasoconstrictors;
  • EDNO–cGMP pathway in transitional pulmonary circulation;
  • persistent pulmonary hypertension of newborn (PPHN);
  • pulmonary endothelium in PPHN;
  • perinatal pulmonary circulation regulation - integrated activity

Summary

This chapter contains sections titled:

  • Introduction

  • Endothelium and the Fetal Pulmonary Circulation

  • Endothelium-Derived Vasoconstrictors in the Fetal Pulmonary Circulation

  • Suppressed Endotheliumdependent Vasodilator Activity in Fetal Pulmonary Circulation

  • Transition of the Pulmonary Circulation at Birth: A Shift in the Balance of Vasodilators and Vasoconstrictors from the Endothelium

  • Importance of the EDNO-cGMP Pathway in the Transitional Pulmonary Circulation

  • Pulmonary Endothelium in PPHN

  • Conclusions and Perspectives

  • References