25. Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis

  1. Norbert F. Voelkel5 and
  2. Sharon Rounds Chief6,7
  1. Mark R. Nicolls1,
  2. Rasa Tamosiuniene2,
  3. Ashok N. Babu3,4 and
  4. Norbert F. Voelkel5

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch25

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Nicolls, M. R., Tamosiuniene, R., Babu, A. N. and Voelkel, N. F. (2009) Interactions of Pulmonary Endothelial Cells with Immune Cells and Platelets: Implications for Disease Pathogenesis, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch25

Editor Information

  1. 5

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 6

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 7

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Divisions of Pulmonary and Critical Care Medicine, Immunology and Rheumatology, Stanford University School of Medicine, VA Palo Alto Health Care System, Palo Alto CA 94306, USA

  2. 2

    Palo Alto Institute of Research Education, VA Palo Alto Health Care System, Stanford University, Palo Alto CA 94306, USA

  3. 3

    Cardiovascular Surgery, University of Colorado Health Sciences Center, Aurora, CO 80045, USA

  4. 4

    Department of Medicine, University of Colorado Health Sciences Center, Aurora, CO, USA

  5. 5

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • pulmonary vascular endothelial cells (ECs) and immune system cells;
  • quiescent and inflamed endothelium;
  • ECs as antigen-presenting cells (APCs) - critical to maladaptive tissue remodeling;
  • innate immune system - cells and molecules defending host from injury;
  • leukocyte transmigration across vascular endothelium;
  • neutrophils in innate immune responses;
  • Natural killer (NK) cells in innate immune response;
  • mast cells, eosinophils and basophils;
  • T cell receptor (TCR)

Summary

This chapter contains sections titled:

  • Introduction

  • Innate Immunity

  • Adaptive Immunity

  • Conclusions and Perspectives

  • References