26. Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease

  1. Norbert F. Voelkel3 and
  2. Sharon Rounds Chief4,5
  1. Norbert F. Voelkel3 and
  2. Ramesh Natarajan1,2

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch26

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Voelkel, N. F. and Natarajan, R. (2009) Role of the Endothelium in Emphysema: Emphysema – A Lung Microvascular Disease, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch26

Editor Information

  1. 3

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 4

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 5

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Virginia Commonwealth University, Richmond VA 23298, USA

  2. 2

    Victoria Johnson Center of Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA, USA

  3. 3

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • endothelium in emphysema and lung microvascular disease;
  • lung structure maintenance program (LSMP);
  • EC apoptosis;
  • VEGF receptor blockade and emphysema;
  • VEGF expression reduced (impaired) in emphysema;
  • TRAF2, tumor necrosis factor receptor-associated factor-2;
  • immune mechanisms in emphysemagenesis;
  • ECs as antigen-presenting cells (APCs);
  • lung ECs and emphysematous lung structure repair

Summary

This chapter contains sections titled:

  • Introduction

  • Emphysema: A Failure of the Lung Structure Maintenance Program

  • EC Apoptosis

  • VEGF Receptor Blockade Causes Emphysema

  • VEGF: The Lynch Pin of Emphysema Pathogenesis

  • Why is VEGF Expression Reduced (Impaired) in Emphysema?

  • Immune Mechanisms in Emphysemagenesis

  • Lung ECs and Repair of the Emphysematous Lung Structure

  • Conclusions and Perspectives

  • References