27. Pulmonary Endothelium and Pulmonary Hypertension

  1. Norbert F. Voelkel3 and
  2. Sharon Rounds Chief4,5
  1. Rubin M. Tuder1 and
  2. Serpil C. Erzurum2

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch27

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Tuder, R. M. and Erzurum, S. C. (2009) Pulmonary Endothelium and Pulmonary Hypertension, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch27

Editor Information

  1. 3

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 4

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 5

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Program in Translational Lung Research, Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver School of Medicine, Aurora, CO, 80045, USA

  2. 2

    Department of Pathobiology and Respiratory Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490



  • exuberant EC proliferation and misguided angiogenesis in pulmonary hypertension;
  • chronic obstructive pulmonary diseases (COPDs);
  • associated diseases of PAH (APAH);
  • EC pathobiology novel concepts in pulmonary hypertension;
  • pulmonary endothelium and pulmonary hypertension;
  • vascular progenitor cells in pulmonary arteries;
  • endothelium role in pulmonary hypertension and IPAH;
  • Human herpesvirus (HHV)-8 and proliferative switch of pulmonary ECs;
  • HIV-associated pulmonary hypertension


This chapter contains sections titled:

  • Introduction

  • Exuberant EC Proliferation and Misguided Angiogenesis in Pulmonary Hypertension

  • Vascular Progenitor Cells in Pulmonary Arteries

  • Metabolic Shift of Hypertensive Pulmonary Vascular Cells in Pulmonary Hypertension

  • More than Just Pulmonary Vascular Cells in Pulmonary Hypertension: Role of Bone Marrow

  • EC Dysfunction: More than Just IPAH

  • Conclusions and Perspectives

  • Acknowledgments

  • References