29. Pulmonary Endothelium in Thromboembolism

  1. Norbert F. Voelkel2 and
  2. Sharon Rounds Chief3,4
  1. Irene M. Lang

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch29

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Lang, I. M. (2009) Pulmonary Endothelium in Thromboembolism, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch29

Editor Information

  1. 2

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 3

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 4

    Medical Center, Providence, RI 02908, USA

Author Information

  1. Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, 1090 Vienna, Austria

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490



  • pulmonary endothelium in thromboembolism;
  • abnormal thrombus formation and resolution in vascular disorders;
  • endothelium and coagulation;
  • chronic thromboembolic pulmonary hypertension (CTEPH);
  • blood coagulation and hemostasis - defense mechanisms against bleeding;
  • lung endothelium in abnormal clot clearance and in situ thrombosis;
  • serial analysis of gene expression in venous thrombi;
  • platelet and EC crosstalk in venous thrombosis;
  • vascular remodeling process and thrombus resolution/organization


This chapter contains sections titled:

  • Introduction

  • The Endothelium and Coagulation

  • The Endothelium and Thrombosis

  • Characteristics of Lung Endothelium

  • Endothelium of the Deep Veins

  • Role of Lung Endothelium in Normal Clot Clearance – EC-Dependent Fibrinolysis

  • Rate and Sequence of Thrombus Organization in the Deep Veins

  • Vascular Remodeling in Pulmonary Embolism

  • Role of Lung Endothelium in Abnormal Clot Clearance and Mechanisms of In Situ Thrombosis

  • Candidate Gene Expression Analysis in Nonresolving Thrombi

  • Angiogenesis in Thrombus Resolution

  • Serial Analysis of Gene Expression in Venous Thrombi

  • Thrombosis, The Endothelium, and Regulation of Vascular Tone

  • Cross-Talk between ECS and Platelets in Venous Thrombosis

  • Conclusions and Perspectives

  • References