6. Pulmonary Endothelium and Nitric Oxide

  1. Norbert F. Voelkel4 and
  2. Sharon Rounds Chief5,6
  1. Yunchao Su1 and
  2. Edward R. Block2,3

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch6

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Su, Y. and Block, E. R. (2009) Pulmonary Endothelium and Nitric Oxide, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch6

Editor Information

  1. 4

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 5

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 6

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA

  2. 2

    Department of Medicine, University of Florida-Gainesville School of Medicine, Gainesville, FL 32610, USA

  3. 3

    Research Service, Malcom Randall Veterans Affairs Medical Center, Gainesville, FL, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490



  • pulmonary endothelium and nitric oxide;
  • nitric oxide (NO) - potent signaling molecule;
  • NO in pulmonary vascular tone regulation;
  • NO in leukocyte–and platelet–endothelium interactions;
  • endothelial L-Arginine availability in NO production;
  • lung endothelial NO signaling arginase;
  • eNOS in lung endothelial NO signaling;
  • eNOS association with cytoskeleton and cellular proteins;
  • NO in chronic obstructive pulmonary diseases


This chapter contains sections titled:

  • Introduction

  • Function of Lung Endothelial Signaling

  • L-Arginine in Lung Endothelial no Signaling

  • eNOS in Lung Endothelial NO Signaling

  • Biological Fate of NO from Lung Endothelium

  • No Signaling in Pathophysiology of Pulmonary Diseases

  • Conclusions and Perspectives

  • References