9. Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels

  1. Norbert F. Voelkel5 and
  2. Sharon Rounds Chief6,7
  1. Donna L. Cioffi1,4,
  2. Songwei Wu2,4 and
  3. Troy Stevens2,3,4

Published Online: 11 SEP 2009

DOI: 10.1002/9780470747490.ch9

The Pulmonary Endothelium: Function in health and disease

The Pulmonary Endothelium: Function in health and disease

How to Cite

Cioffi, D. L., Wu, S. and Stevens, T. (2009) Lung Endothelial Phenotypes: Insights Derived from the Systematic Study of Calcium Channels, in The Pulmonary Endothelium: Function in health and disease (eds N. F. Voelkel and S. Rounds), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747490.ch9

Editor Information

  1. 5

    The E. Raymond Fenton Professor of Pulmonary Research, Director, Victoria Johnson Center for Pulmonary Obstructive Disease Research, Pulmonary and Critical Care Medicine Division, Virginia Commonwealth University, Richmond, VA 23298, USA

  2. 6

    Alpert Medical School of Brown University, Medical Service, Providence VA, USA

  3. 7

    Medical Center, Providence, RI 02908, USA

Author Information

  1. 1

    Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA

  2. 2

    Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL 36688, USA

  3. 3

    Departments of Medicine, University of South Alabama College of Medicine, Mobile, AL 36688, USA

  4. 4

    Center for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA

Publication History

  1. Published Online: 11 SEP 2009
  2. Published Print: 16 OCT 2009

ISBN Information

Print ISBN: 9780470723616

Online ISBN: 9780470747490

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Keywords:

  • lung endothelial phenotypes;
  • pulmonary artery, capillary, and vein endothelium heterogeneity;
  • pulmonary vein ECs (PVECs);
  • pulmonary artery and capillary ECs and unique features;
  • pulmonary microvascular ECs (PMVECs) and Griffonia simplicifolia;
  • thapsiargin rolipram methyl methacrylate vascular cast;
  • reverse transcription polymerase chain reaction (RT-PCR) cloning;
  • TRPV4 activation and EC permeability increase;
  • TRPV4 activation disrupting cell–matrix tethering

Summary

This chapter contains sections titled:

  • Introduction

  • Heterogeneity in Pulmonary Artery, Capillary, and Vein Endothelium

  • Exquisite Fidelity in Calcium Signaling Reveals Lung EC Heterogeneity

  • Conclusions and Perspectives

  • References