Chapter 11. Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets

  1. Saura C. Sahu2 and
  2. Daniel A. Casciano3
  1. Jan Simak

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch11



How to Cite

Simak, J. (2009) Nanotoxicity in Blood: Effects of Engineered Nanomaterials on Platelets, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch11

Editor Information

  1. 2

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 3

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. US Food and Drug Administration, CBER, 1401 Rockville Pike, Rockville, MD, 20852, USA

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803



  • blood nanotoxicity and engineered nanomaterial effects on platelets;
  • designing nontoxic nanomaterials with optimum biocompatibility;
  • biocompatibility of engineered nanomaterials in blood and vasculature;
  • engineered nanomaterial toxicity in blood;
  • reactive oxygen and nitrogen species (RONS);
  • biocompatibility studies and hemolysis;
  • complement activation;
  • and thrombogenicity;
  • activated partial thromboplastin time (APTT);
  • effect of nanostructure properties on platelets;
  • PLT–nanomaterial interactions and platelet flow cytometry;
  • tissue scaffolds for tissue engineering and nanotechnology development


This chapter contains sections titled:

  • Introduction

  • Toxicity of Engineered Nanomaterials in Blood

  • Blood Platelets

  • Possible Adverse Effects of Nanomaterial Interaction with Platelets In Vivo

  • Methods for Evaluation of Effects of Nanomaterials on Platelets

  • Studies on Effects of Different Types of Nanomaterials on Platelets

  • Platelet Coating with Nanomaterials

  • Nanomaterials Designed to Inhibit or Activate Platelets

  • Tissue Scaffolds

  • Effect of Nanostructure Properties on Platelets

  • Conclusion

  • References