Chapter 18. In Vitro Models for Nanotoxicity Testing

  1. Saura C. Sahu2 and
  2. Daniel A. Casciano3
  1. Yinfa Ma

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch18



How to Cite

Ma, Y. (2009) In Vitro Models for Nanotoxicity Testing, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch18

Editor Information

  1. 2

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 3

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. Department of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, USA

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803



  • nanotoxicity testing;
  • nanotechnology and nanomaterial applications - leading technologies;
  • long-term effects of nanoparticles on human health;
  • nanoparticle characterization;
  • transmission electron microscopy (TEM);
  • scanning electron microscopy (SEM);
  • light scattering and zeta-meter;
  • inductively coupled plasma mass spectrometry (ICP-MS) and metal impurities in nanoparticles;
  • Malondialdehyde (MDA) - marker measuring lipid peroxidation;
  • in vitro cytotoxicity study of nanoparticles and data analysis


This chapter contains sections titled:

  • Introduction

  • Characterization of Nanoparticles

  • Cell Line Selections for In Vitro Nanotoxicity Study

  • Biomarker Analysis

  • Cell Imaging for In Vitro Nanotoxicity Analysis

  • Dosimetry for In Vitro Study

  • Effect of Nanoparticle Morphology on the Results of Nanotoxicity Study

  • Data Analysis

  • References