Chapter 19. In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles

  1. Saura C. Sahu3 and
  2. Daniel A. Casciano4
  1. Fabian Blank1,
  2. Peter Gehr2 and
  3. Barbara Rothen-Rutishauser2

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch19



How to Cite

Blank, F., Gehr, P. and Rothen-Rutishauser, B. (2009) In Vitro Human Lung Cell Culture Models to Study the Toxic Potential of Nanoparticles, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch19

Editor Information

  1. 3

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 4

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. 1

    Telethon Institute for Child Health Research, 100 Roberts Road, Subiaco, WA 6008 Australia

  2. 2

    Institute of Anatomy, Division of Histology, University of Bern, Baltzerstrasse 2, Bern, Switzerland

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803



  • nanoparticle toxic potential;
  • nanoparticle interaction with biological systems;
  • characterization of nanomaterial dose in toxicological investigation;
  • particle–cell interactions;
  • cell culture models of lung;
  • human cell culture models for nanotoxicological studies;
  • particle–cell interaction models;
  • mesothelial cell lines and long multiwalled carbon nanotubes;
  • cell cultures assessing combustion-derived ultrafine particle toxicity;
  • cell culture models and particle–cell interactions mechanisms in lung


This chapter contains sections titled:

  • Introduction

  • Interaction of Nanoparticles with Biological Systems

  • Barriers to Nanoparticle Distribution

  • Models to Study Particle–Cell Interactions

  • Conclusion

  • References