Chapter 20. Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms

  1. Saura C. Sahu4 and
  2. Daniel A. Casciano5
  1. Thomas R. Pisanic II1,
  2. Sungho Jin2 and
  3. Veronica I. Shubayev3

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch20

Nanotoxicity

Nanotoxicity

How to Cite

Pisanic, T. R., Jin, S. and Shubayev, V. I. (2009) Iron Oxide Magnetic Nanoparticle Nanotoxicity: Incidence and Mechanisms, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch20

Editor Information

  1. 4

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 5

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. 1

    Magnesensors, Inc., San Diego, CA, USA

  2. 2

    Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093-0411, USA

  3. 3

    Department of Anesthesiology and Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92093-0629, USA

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803

SEARCH

Keywords:

  • iron oxide magnetic nanoparticle nanotoxicity;
  • iron oxide magnetic nanoparticles (IOMNPs);
  • IOMNP-induced nanotoxicity;
  • iron oxide magnetic nanoparticles in biomedical applications;
  • IOMNPs - contrast agents in magnetic resonance imaging (MRI);
  • iron oxide magnetic nanoparticles in biomedicine;
  • IOMNP nanotoxicity mechanisms;
  • ROS generation from IOMNPs;
  • signalling pathways and epidermal growth factor receptor (EGFR);
  • future of IOMNP nanotoxicological testing

Summary

This chapter contains sections titled:

  • Introduction

  • Iron Oxide Magnetic Nanoparticles in Current Biomedical Applications

  • Nanotoxicology for Iron Oxide Magnetic Nanoparticles

  • Toxicity Studies

  • Mechanisms of IOMNP Nanotoxicity

  • Long-Term Nanotoxicity of IOMNPs – General and Neurological Toxicity

  • Considerations for the Future of IOMNP Nanotoxicological Testing

  • Conclusions

  • References