Chapter 3. Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines

  1. Saura C. Sahu2 and
  2. Daniel A. Casciano3
  1. Lea Ann Dailey

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch3

Nanotoxicity

Nanotoxicity

How to Cite

Dailey, L. A. (2009) Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch3

Editor Information

  1. 2

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 3

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. King's College London, Pharmaceutical Science Division, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803

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Keywords:

  • inhaled nanomedicines and toxicity study design;
  • nanotechnology and healthcare applications;
  • quantum dots - imaging contrast agents in diagnostic applications;
  • respiratory nanotoxicology and inhaled nanomedicine research;
  • nanoparticulate drug carrier system and cell or cell organelle access;
  • lung retention times of drug control research;
  • particle surface chemistry and slowing clearance by MPS;
  • nanoparticulate pulmonary drug delivery;
  • surface acoustic wave energy for monodisperse nanoparticles;
  • nanotechnology exploitation and inhalation therapy improvement

Summary

This chapter contains sections titled:

  • Introduction

  • What are Inhaled Nanomedicines Designed to Accomplish and How Does their Structure Contribute to this Aim?

  • What are the Primary Physico-chemical Characteristics of Inhaled Nanomedicines that Distinguish them from Particles Commonly Studied in Environmental and Occupational Respiratory Toxicology?

  • What are the Likely Implications of Differences in Exposure Patterns to Inhaled Nanomedicines vs. Manufactured or Ambient Nanoparticles on Respiratory Health?

  • References