Chapter 3. Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines

  1. Saura C. Sahu2 and
  2. Daniel A. Casciano3
  1. Lea Ann Dailey

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch3



How to Cite

Dailey, L. A. (2009) Considerations for the Design of Toxicity Studies of Inhaled Nanomedicines, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch3

Editor Information

  1. 2

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 3

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. King's College London, Pharmaceutical Science Division, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, United Kingdom

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803



  • inhaled nanomedicines and toxicity study design;
  • nanotechnology and healthcare applications;
  • quantum dots - imaging contrast agents in diagnostic applications;
  • respiratory nanotoxicology and inhaled nanomedicine research;
  • nanoparticulate drug carrier system and cell or cell organelle access;
  • lung retention times of drug control research;
  • particle surface chemistry and slowing clearance by MPS;
  • nanoparticulate pulmonary drug delivery;
  • surface acoustic wave energy for monodisperse nanoparticles;
  • nanotechnology exploitation and inhalation therapy improvement


This chapter contains sections titled:

  • Introduction

  • What are Inhaled Nanomedicines Designed to Accomplish and How Does their Structure Contribute to this Aim?

  • What are the Primary Physico-chemical Characteristics of Inhaled Nanomedicines that Distinguish them from Particles Commonly Studied in Environmental and Occupational Respiratory Toxicology?

  • What are the Likely Implications of Differences in Exposure Patterns to Inhaled Nanomedicines vs. Manufactured or Ambient Nanoparticles on Respiratory Health?

  • References