Chapter 4. High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm

  1. Saura C. Sahu2 and
  2. Daniel A. Casciano3
  1. Craig A. Poland,
  2. Rodger Duffin and
  3. Ken Donaldson

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch4



How to Cite

Poland, C. A., Duffin, R. and Donaldson, K. (2009) High Aspect Ratio Nanoparticles and the Fibre Pathogenicity Paradigm, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch4

Editor Information

  1. 2

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 3

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. University of Edinburgh, ELEGI Colt Laboratory, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, United Kingdom

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803



  • high aspect ratio nanoparticles (HARNs) and fibre pathogenicity paradigm;
  • HARN - nanoparticle with length many times that of width;
  • carbon nanotubes (CNTs) - attracting industrial and toxicological scientists;
  • nanotubes for nano-size and fibre-like dimensions;
  • fibre pathogenicity paradigm - dimension, durability and dose (the 3 Ds);
  • surface area - key metric driving inflammation with low toxicity particles;
  • DPPC suspensions as CNT surfactant;
  • HARN/fibre testing on mesothelium;
  • reactive oxygen species in pathogenicity of particles;
  • CNT toxicity and possible health effects - safe nanotechnology challenges


This chapter contains sections titled:

  • High Aspect Ratio Nanoparticles (HARNs)

  • Asbestos and Disease

  • Fibre Pathogenicity Paradigm: Dimension, Durability and Dose (the 3 Ds)

  • Challenges of Carrying Out Toxicological Testing with HARNs

  • Testing for HARN/Fibre Effects on the Mesothelium

  • Mechanism of the Long Fibre/CNT Effect

  • Summary and Conclusions

  • References