Chapter 8. Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials

  1. Saura C. Sahu3 and
  2. Daniel A. Casciano4
  1. David B. Warheit1,
  2. Kenneth L. Reed1 and
  3. Christie M. Sayes2

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch8

Nanotoxicity

Nanotoxicity

How to Cite

Warheit, D. B., Reed, K. L. and Sayes, C. M. (2009) Developing Bioassay Methods for Evaluating Pulmonary Hazards from Nanoscale or Fine Quartz/Titanium Dioxide Particulate Materials, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch8

Editor Information

  1. 3

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 4

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. 1

    DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware, USA

  2. 2

    Department of Veterinary Physiology & Pharmacology, College of Veterinary Medicine and Biomedical Sciences, Texas A & M University, College Station, TX 77843-4466, USA

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803

SEARCH

Keywords:

  • bioassay methods evaluating pulmonary hazards from nanoscale;
  • fine quartz/titanium dioxide particulate materials;
  • nanoscale particle-types using gas phase flame reactions;
  • nanoparticle types and hazard testing;
  • experimental design for pulmonary bioassay studies;
  • bronchoalveolar lavage fluid (BALF) studies;
  • pulmonary bioassay studies of fine and nanoscale TiO2 particle types;
  • pulmonary effects in dose-response/time-course protocol and BALF biomarkers;
  • nanoscale/fine quartz particle lung bioassay study;
  • pulmonary bioassays and appropriate benchmark control particle samples

Summary

This chapter contains sections titled:

  • Introduction

  • A Typical Experimental Design for Pulmonary Bioassay Studies

  • Results of Bioassays

  • Summary

  • References