Chapter 9. Nanoparticles: Is Neurotoxicity a Concern?

  1. Saura C. Sahu4 and
  2. Daniel A. Casciano5
  1. Jianyong Wang1,
  2. Wenjun Sun2 and
  3. Syed F. Ali3

Published Online: 18 AUG 2009

DOI: 10.1002/9780470747803.ch9



How to Cite

Wang, J., Sun, W. and Ali, S. F. (2009) Nanoparticles: Is Neurotoxicity a Concern?, in Nanotoxicity (eds S. C. Sahu and D. A. Casciano), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470747803.ch9

Editor Information

  1. 4

    Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA

  2. 5

    Department for Applied Science, University of Arkansas at Little Rock, Little Rock, AR, USA

Author Information

  1. 1

    Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, HFD-540, 10903 New Hampshire Ave, Silver Spring, Maryland 20993, USA

  2. 2

    Department of Neurology, Xuanwu Hospital of the Capital Medical University, Beijing, China 100053

  3. 3

    Division of Neurotoxicology, National Center for Toxicological Research, Food and Drug Administration, HFT-132, 3900 NCTR Rd, Jefferson, Arkansas 72079, USA

Publication History

  1. Published Online: 18 AUG 2009
  2. Published Print: 21 AUG 2009

ISBN Information

Print ISBN: 9780470741375

Online ISBN: 9780470747803



  • nanoparticles and neurotoxicity - matter of concern;
  • nanoparticles with novel physico-chemical properties and mechanisms of injury;
  • nanotechnology - benefits and dangers to humanity and ecosystem;
  • nanoparticle and nanotube nanomaterials and foreseeable hazards;
  • cardiovascular effects of particulate pollution;
  • polymers and ceramic nanoparticles in drug delivery systems;
  • nanoparticles and CNS access - Inhalation route in atmospheric pollutants;
  • nanoparticles on brain function and modifying BBB function;
  • oxidative stress and Alzheimer's disease;
  • nanoparticles and toxicological outcomes in organs


This chapter contains sections titled:

  • Background

  • How do Nanoparticles Gain Access to the CNS?

  • Mechanisms for Potential Neurotoxicity Induced by Nanoparticles

  • Evidence for Neurotoxicity Induced by Various Nanoparticles

  • Future Research Needed

  • References