Chapter 1. Biotransformations in Small-Molecule Pharmaceutical Development

  1. John Whittall3 and
  2. Peter Sutton4
  1. Joseph P. Adams4,
  2. Andrew J. Collis1,
  3. Richard K. Henderson2 and
  4. Peter W. Sutton4

Published Online: 15 DEC 2009

DOI: 10.1002/9780470748589.ch1

Practical Methods for Biocatalysis and Biotransformations

Practical Methods for Biocatalysis and Biotransformations

How to Cite

Adams, J. P., Collis, A. J., Henderson, R. K. and Sutton, P. W. (2009) Biotransformations in Small-Molecule Pharmaceutical Development, in Practical Methods for Biocatalysis and Biotransformations (eds J. Whittall and P. Sutton), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470748589.ch1

Editor Information

  1. 3

    Manchester Interdisciplinary Biocentre, University of Manchester, United Kingdom

  2. 4

    GlaxoSmithKline, Synthetic Chemistry, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK

Author Information

  1. 1

    GlaxoSmithKline, Biotechnology and Environmental Shared Service, North Lonsdale Road, Ulverston, Cumbria LA12 9DR, UK

  2. 2

    GlaxoSmithKline, Centre of Excellence for Sustainability and Environment, Park Road, Ware, Hertfordshire SG12 0DP, UK

  3. 4

    GlaxoSmithKline, Synthetic Chemistry, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK

Publication History

  1. Published Online: 15 DEC 2009
  2. Published Print: 18 DEC 2009

ISBN Information

Print ISBN: 9780470519271

Online ISBN: 9780470748589

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Keywords:

  • biotransformations in small-molecule pharmaceutical development;
  • new molecular entities (NMEs) and biologics, reaching the markets;
  • active pharmaceutical ingredient (API);
  • biocatalysis - current status;
  • sparse incorporation of biocatalysts into process chemist's toolbox;
  • application of biocatalysis in pharmaceutical industry;
  • uridine diphosphate glucuronide transferase cycle;
  • N-acetyl-D-neuraminic acid (NANA) - synthesized using NANA aldolase;
  • enzyme immobilization - enzymatic DKR of thioester intermediate of odanacatib;
  • Green Chemistry - use of biocatalysis in APIs manufacture

Summary

This chapter contains sections titled:

  • Introduction

  • Current Status of Biocatalysis

  • Application of Biocatalysis in the Pharmaceutical Industry

  • Enzymes in Organic Solvent

  • Enzyme Immobilization

  • Green Chemistry

  • Future Perspectives

  • Concluding Remarks

  • Acknowledgements

  • References