Chapter 11. Enzymatic Oxidation Chemistry

  1. John Whittall11 and
  2. Peter Sutton12
  1. Andrew J. Ellis1,
  2. Renate Reiss1,
  3. Timothy J. Snape2,
  4. Nicholas J. Turner1,
  5. Fabio Pezzotti2,
  6. Helene Therisod2,
  7. Michel Therisod2,
  8. Bjoern-Arne Kaup3,
  9. Umberto Piantini4,
  10. Matthias Wüst4,
  11. Jens Schrader3,
  12. Cinzia Chiappe5,
  13. Stefano Colonna6,
  14. Nicoletta Gaggero6,
  15. Sara Pellegrino6,
  16. Francesca Zambianchi7,
  17. Anett Kirschner8,
  18. Uwe T. Bornscheuer8,
  19. Gideon Grogan9,
  20. Cheryl Hill9,
  21. Shaozhao Wang10,
  22. Jianzhong Yang10 and
  23. Peter C. K. Lau10

Published Online: 15 DEC 2009

DOI: 10.1002/9780470748589.ch11

Practical Methods for Biocatalysis and Biotransformations

Practical Methods for Biocatalysis and Biotransformations

How to Cite

Ellis, A. J., Reiss, R., Snape, T. J., Turner, N. J., Pezzotti, F., Therisod, H., Therisod, M., Kaup, B.-A., Piantini, U., Wüst, M., Schrader, J., Chiappe, C., Colonna, S., Gaggero, N., Pellegrino, S., Zambianchi, F., Kirschner, A., Bornscheuer, U. T., Grogan, G., Hill, C., Wang, S., Yang, J. and Lau, P. C. K. (2009) Enzymatic Oxidation Chemistry, in Practical Methods for Biocatalysis and Biotransformations (eds J. Whittall and P. Sutton), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470748589.ch11

Editor Information

  1. 11

    Manchester Interdisciplinary Biocentre, University of Manchester, United Kingdom

  2. 12

    GlaxoSmithKline, Synthetic Chemistry, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK

Author Information

  1. 1

    School of Chemistry, Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK

  2. 2

    ECBB, ICMMO, Univ Paris-Sud, UMR 8182, F-91405 Orsay, France

  3. 3

    DECHEMA e.V., Karl-Winnacker-Institut, Biochemical Engineering Group, Theodor-Heuss-Allee 25, 60486 Frankfurt, Germany

  4. 4

    Institute of Life Technologies, University of Applied Sciences Valais, Route du Rawyl 47, 1950 Sion, Switzerland

  5. 5

    Dipartimento di Chimica e Chimica Industriale, Universit di Pisa, 56126 Pisa, Italy

  6. 6

    Dipartimento di Scienze Molecolari Applicate ai Biosistemi (DISMAB), Facoltà di Farmacia, Università degli Studi di Milano, via Venezian 21, 20133 Milano, Italy

  7. 7

    Istituto di Chimica del Riconoscimento Molecolare, CNR, via Mario Bianco 9, 20131 Milano, Italy

  8. 8

    Department of Biotechnology and Enzyme Catalysis, Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Str. 4, 17487 Greifswald, Germany

  9. 9

    York Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York, YO10 5YW, UK

  10. 10

    Biotechnology Research Institute, National Research Council Canada, Montreal, Quebec H4P 2R2, Canada

Publication History

  1. Published Online: 15 DEC 2009
  2. Published Print: 18 DEC 2009

ISBN Information

Print ISBN: 9780470519271

Online ISBN: 9780470748589



  • enzymatic oxidation chemistry;
  • enantioselective amine oxidase (MAO-N) in combination with nonselective chemical reducing agent;
  • glucose oxidase-catalysed synthesis of aldonic acids;
  • oxidation and halo-hydroxylation of monoterpenes;
  • oxidation of geraniol by CPO;
  • chloroperoxidase-catalyzed oxidation of phenyl methylsulfide in ionic liquids;
  • heme enzyme chloroperoxidase (CPO), by marine fungus Caldariomyces fumago;
  • acinetobacter calcoaceticus (CHMO) as catalyst;
  • kinetic resolution of racemic 3-phenylbutan-2-one;
  • enzymatic hydrolysis of (S)-1-phenylethyl acetate


This chapter contains sections titled:

  • Monoamine Oxidase-catalysed Reactions: Application Towards the Chemo-enzymatic Deracemization of the Alkaloid (±)-Crispine A

  • Glucose Oxidase-catalysed Synthesis of Aldonic Acids

  • Oxidation and Halo-hydroxylation of Monoterpenes with Chloroperoxidase from Leptoxyphium fumago

  • Chloroperoxidase-catalyzed Oxidation of Phenyl Methylsulfide in Ionic Liquids

  • Stereoselective Synthesis of β-Hydroxy Sulfoxides Catalyzed by Cyclohexanone Monooxygenase

  • Enantioselective Kinetic Resolution of Racemic 3-Phenylbutan-2-one Using a Baeyer–Villiger Monooxygenase

  • Desymmetrization of 1-Methylbicyclo[3.3.0]octane-2,8-dione by the Retro-claisenase 6-Oxo Camphor Hydrolase

  • Synthesis of Optically Pure Chiral Lactones by Cyclopentadecanone Monooxygenase-catalyzed Baeyer–Villiger Oxidations