Chapter 13. Homology Modelling of G Protein-Coupled Receptors

  1. David R. Poyner2 and
  2. Mark Wheatley3
  1. John Simms

Published Online: 25 JAN 2010

DOI: 10.1002/9780470749210.ch13

G Protein-Coupled Receptors: Essential Methods

G Protein-Coupled Receptors: Essential Methods

How to Cite

Simms, J. (2010) Homology Modelling of G Protein-Coupled Receptors, in G Protein-Coupled Receptors: Essential Methods (eds D. R. Poyner and M. Wheatley), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9780470749210.ch13

Editor Information

  1. 2

    Pharmaceutical and Biological Sciences, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK

  2. 3

    School of Biosciences, Birmingham University, Birmingham B15 2TT, UK

Author Information

  1. Department of Pharmacology, University of Monash, Clayton, Victoria 3800, Australia

Publication History

  1. Published Online: 25 JAN 2010
  2. Published Print: 22 JAN 2010

ISBN Information

Print ISBN: 9780470749142

Online ISBN: 9780470749210

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Keywords:

  • homology modelling of G protein-coupled receptors;
  • functional characterization of protein sequence and three-dimensional (3D) structure of protein;
  • homology modelling protocol and selection structural template from Protein Data Bank (PDB);
  • sequence for query structure - referred to as ‘target’;
  • MODELLER, installed on local or networked computer;
  • variable ‘sequence’ in MODELLER Python script;
  • executing MODELLER input in generating homology models;
  • Protocol 13.4 modelling loops in GPCRs;
  • automated methods for models of GPCRs generation;
  • ROBETTA server - automated front end to successful ROSETTA method

Summary

This chapter contains sections titled:

  • Introduction

  • Methods and approaches

  • Troubleshooting

  • Automated methods for generating models of GPCRs

  • References