Chapter 8. Adjuvant Radiotherapy and Chemoradiotherapy in the Treatment of Rectal Cancer

  1. John H. Scholefield1,
  2. Axel Grothey2,
  3. Herand Abcarian3 and
  4. Tim Maughan4
  1. Rachel Cooper and
  2. David Sebag-Montefiore

Published Online: 14 JAN 2008

DOI: 10.1002/9780470753231.ch8

Challenges in Colorectal Cancer

Challenges in Colorectal Cancer

How to Cite

Cooper, R. and Sebag-Montefiore, D. (2006) Adjuvant Radiotherapy and Chemoradiotherapy in the Treatment of Rectal Cancer, in Challenges in Colorectal Cancer (eds J. H. Scholefield, A. Grothey, H. Abcarian and T. Maughan), Blackwell Publishing Ltd, Malden, Massachusetts, USA. doi: 10.1002/9780470753231.ch8

Editor Information

  1. 1

    Professor of Surgery, University Hospital, Nottingham, UK

  2. 2

    Professor, Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota, USA

  3. 3

    Turi Josefsen Professor and Chairman, Department of Surgery, University of Illinois College of Medicine, Chicago, Illinois, USA

  4. 4

    Professor of Cancer Studies, University of Cardiff, Cardiff, UK

Publication History

  1. Published Online: 14 JAN 2008
  2. Published Print: 1 JAN 2006

ISBN Information

Print ISBN: 9781405127066

Online ISBN: 9780470753231



  • radiotherapy;
  • chemoradiotherapy;
  • rectal cancer;
  • surgery;
  • adhesions


This chapter contains section titled:

  • Introduction

  • What is the evidence base for adjuvant radiotherapy?

  • What is the benefit of adjuvant radiotherapy in addition to total mesorectal excision surgery?

  • Is preoperative radiotherapy superior to postoperative radiotherapy?

  • What is the benefit of the addition of chemotherapy to long-course radiotherapy?

  • What is the evidence for the role of pelvic MRI in preoperative staging?

  • What are the late effects of adjuvant radiotherapy?

  • Why do international differences in selection policy in patients with resectable rectal cancer persist?

  • Preoperative chemoradiotherapy for locally advanced rectal cancer

  • Can adjuvant treatment achieve sphincter preservation?

  • Conclusion