Chapter 25. Paraproteinaemic Demyelinating Neuropathy

  1. Richard Hughes17,
  2. Michael Brainin18 and
  3. Nils Erik Gilhus19
  1. R. D. M. Hadden1,
  2. E. Nobile-Orazio2,
  3. C. Sommer3,
  4. A. Hahn4,
  5. I. Illa5,
  6. E. Morra6,
  7. J. Pollard7,
  8. R. Hughes8,
  9. P. Bouche9,
  10. D. Cornblath10,
  11. E. Evers11,
  12. C. L. Koski12,
  13. J. M. Léger13,
  14. P. Van den Bergh14,
  15. P. van Doorn15 and
  16. I. N. van Schaik16

Published Online: 14 JAN 2008

DOI: 10.1002/9780470753279.ch25

European Handbook of Neurological Management

European Handbook of Neurological Management

How to Cite

Hadden, R. D. M., Nobile-Orazio, E., Sommer, C., Hahn, A., Illa, I., Morra, E., Pollard, J., Hughes, R., Bouche, P., Cornblath, D., Evers, E., Koski, C. L., Léger, J. M., Van den Bergh, P., van Doorn, P. and van Schaik, I. N. (2006) Paraproteinaemic Demyelinating Neuropathy, in European Handbook of Neurological Management (eds R. Hughes, M. Brainin and N. E. Gilhus), Blackwell Publishing, Inc., Malden, Massachusetts, USA. doi: 10.1002/9780470753279.ch25

Editor Information

  1. 17

    Professor of Neurology, Department of Clinical Neuroscience, King's College London, London, UK

  2. 18

    Professor of Clinical Neurology, Donauklinikum Gugging and Donau-Universität, Krems, Austria

  3. 19

    Professor of Neurology, University of Bergen and Haukeland University Hospital, Bergen, Norway

Author Information

  1. 1

    Department of Neurology, King's College Hospital, London, UK

  2. 2

    Department of Neurological Science, University of Milan, Milan, Italy

  3. 3

    Department of Neurology, University of Wurzburg, Wurzburg, Germany

  4. 4

    Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada

  5. 5

    Department of Neurology, Hospital Sta. Creu i Sant Pau, Barcelona, Spain

  6. 6

    Department of Haematology, Niguarda Hospital, Milan, Italy

  7. 7

    Department of Medicine, University of Sydney, Sydney, Australia

  8. 8

    Department of Neuroimmunology, King's College, London, UK

  9. 9

    Department of Neurophysiology, CHU Pitie-Salpetriere, Paris, France

  10. 10

    Department of Neurology, Johns Hopkins University, Baltimore, MD, USA

  11. 11

    Lay member, Guillan-Barre Syndrome Support Group of the UK, UK

  12. 12

    Department of Neurology, University of Maryland, Baltimore, MD, USA

  13. 13

    Department of Neurology, Faculte de Medecine Pitie-Salpetriere, Paris, France

  14. 14

    Department of Neurology, Clinique Universitaire St-Luc, Brussels, Belgium

  15. 15

    Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands

  16. 16

    Department of Neurology, Academic Medical Centre, Amsterdam, the Netherlands

Publication History

  1. Published Online: 14 JAN 2008
  2. Published Print: 1 JAN 2006

ISBN Information

Print ISBN: 9781405130509

Online ISBN: 9780470753279



  • paraproteinaemic demyelinating neuropathy;
  • disease progression;
  • polyradiculoneuropathy;
  • immunoreactivity;
  • serum immunofixation electrophoresis


This chapter contains section titled:

  • Abstract

  • Objectives

  • Background

  • Search strategy

  • Methods for reaching consensus

  • Results

  • Investigation and classification of the paraprotein

  • Typical syndromes of paraprotein-aemic demyelinating neuropathy

  • Other neuropathy syndromes associated with paraproteinaemia

  • Is the paraprotein causing the neuropathy?

  • Cerebrospinal fluid and nerve biopsy

  • Treatment of paraproteinaemic demyelinating neuropathies

  • Acknowledgement