Chapter 10. Altered Properties of Airway Smooth Muscle in Asthma

  1. Kian Fan Chung
  1. Judith Black Senior Principal Research Fellow Head,
  2. Janette Burgess Wright Fellow,
  3. Brian Oliver Research Fellow and
  4. Lyn Moir Research Fellow

Published Online: 4 JUN 2008

DOI: 10.1002/9780470754221.ch10

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

How to Cite

Black, J., Burgess, J., Oliver, B. and Moir, L. (2008) Altered Properties of Airway Smooth Muscle in Asthma, in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470754221.ch10

Editor Information

  1. Airway Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Author Information

  1. Discipline of Pharmacology, Faculty of Medicine, Room 211 Blackburn Building D06, University of Sydney, Woolcock Institute of Medical Research, NSW 2006, Australia

Publication History

  1. Published Online: 4 JUN 2008
  2. Published Print: 18 APR 2008

ISBN Information

Print ISBN: 9780470060667

Online ISBN: 9780470754221

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Keywords:

  • asthma airway smooth muscle (ASM) - altered properties;
  • extracellular matrix (ECM) and ASM;
  • connective tissue growth factor (CTGF);
  • asthmatic ASM cell PI3K pathway dependence;
  • TGFβ and vascular endothelial growth factor (VEGF);
  • cell–ECM interactions via integrins;
  • integrins - current asthma therapies;
  • smooth muscle cell and pattern recognition receptors (PRRs)

Summary

This chapter contains sections titled:

  • Introduction

  • The extracellular matrix (ECM) and the airway smooth muscle (ASM)

  • ASM and integrins

  • The ASM cell and inflammation

  • The ASM cell and infection

  • References