Chapter 12. Glucocorticoid Actions on Airway Smooth Muscle

  1. Kian Fan Chung
  1. Ian M. Adcock,
  2. Loukia Tsaprouni and
  3. Pank Bhavsar

Published Online: 4 JUN 2008

DOI: 10.1002/9780470754221.ch12

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

How to Cite

Adcock, I. M., Tsaprouni, L. and Bhavsar, P. (2008) Glucocorticoid Actions on Airway Smooth Muscle, in Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology (ed K. F. Chung), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470754221.ch12

Editor Information

  1. Airway Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Author Information

  1. Cell and Molecular Biology, Airways Disease Section, National Heart & Lung Institute, Imperial College London, Dovehouse Street, London SW3 6LY, UK

Publication History

  1. Published Online: 4 JUN 2008
  2. Published Print: 18 APR 2008

ISBN Information

Print ISBN: 9780470060667

Online ISBN: 9780470754221

SEARCH

Keywords:

  • glucocorticoid act and cytosolic glucocorticoid receptors (GR);
  • airway smooth muscle (ASM) airways disease;
  • epithelial-mesenchymal trophic unit (EMTU);
  • glucocorticoid response elements (GREs);
  • GR transactivation and histone acetylation;
  • glucocorticoids in mitogen activated protein kinases (MAPKs);
  • β2-agonist and glucocorticoid action;
  • glucocorticoid antiproliferative activity;
  • asthma drug and ASM migration

Summary

This chapter contains sections titled:

  • Introduction

  • Airway smooth muscle (ASM) in airways disease

  • Gene induction by glucocorticoid receptors (GR)

  • Actions of β2-agonists and glucocorticoids on growth, proliferation, and migration of ASM

  • Summary and conclusions

  • Acknowledgements

  • References